more research

Research

Below are links to some of the most significant scientific papers on each of the molecules.

Nicotinamide Mononucleotide (NMN)

Resveratrol

Berberine

Fisetin

Vitamin D

Vitamin K2

Nicotinamide Mononucleotide (NMN)

“Longevity genes” called sirtuins help you live a longer, healthier life by detecting errors and fixing them. Sirtuins need NAD (nicotinamide adenine dinucleotide) to function. We lose NAD in the body as we age. Nicotinamide mononucleotide (“NMN”) enhances NAD production, helping to keep it at levels usually found in youth.

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism. https://www.sciencedirect.com/science/article/pii/S1550413116304958

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology. https://www.sciencedirect.com/science/article/pii/S221323171930240X

The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell. https://www.sciencedirect.com/science/article/pii/S0092867413007551

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journal. https://www.embopress.org/doi/full/10.15252/embj.201386907

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism. https://www.sciencedirect.com/science/article/pii/S1550413116304958

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.Cell metabolism https://www.sciencedirect.com/science/article/pii/S1550413116304958

NAD Replenishment With Nicotinamide Mononucleotide Protects Blood-Brain Barrier Integrity and Attenuates Delayed Tissue Plasminogen Activator-Induced Haemorrhagic Transformation After Cerebral Ischaemia. Br J Pharmacol http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5647191/

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.Diabetologia https://link.springer.com/article/10.1007/s00125-011-2288-0

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.Cell metabolism https://www.sciencedirect.com/science/article/pii/S1550413116304958

NAD+ Intermediates: The biology and therapeutic potential of NMN and NR.Cell metabolism https://pubmed.ncbi.nlm.nih.gov/29249689-nad-intermediates-the-biology-and-therapeutic-potential-of-nmn-and-nr

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model. BMC Neurology https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-015-0272-x

Effect of Oral Administration of Nicotinamide Mononucleotide on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men. Endocr J https://www.ncbi.nlm.nih.gov/pubmed/31685720

Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front Pharmacol https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27594836/

Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. Hum Genomics https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31823815/

Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats. J Cardiovasc Pharmacol Ther https://www.ncbi.nlm.nih.gov/pubmed/31645107

Nicotinamide Mononucleotide (NMN) Supplementation Ameliorates the Impact of Maternal Obesity in Mice: Comparison With Exercise. Scientific Reports https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678092/

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. GeroScience https://link.springer.com/article/10.1007/s11357-019-00095-x

Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome. Toxicology and applied pharmacology https://www.sciencedirect.com/science/article/pii/S0041008X18304642

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice.Journal of Affective Disorders https://www.sciencedirect.com/science/article/abs/pii/S0165032719322438

Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus. Neuroscience https://www.sciencedirect.com/science/article/abs/pii/S0306452219306827

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Scientific Reports https://www.nature.com/articles/s41598-017-00851-z

Nicotinamide Mononucleotide Inhibits JNK Activation to Reverse Alzheimer Disease. Neurosci Lett https://linkinghub.elsevier.com/retrieve/pii/S030439401730246X

Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia. Neurobiology of Disease https://www.sciencedirect.com/science/article/pii/S0969996116301760

Nicotinamide Mononucleotide Preserves Mitochondrial Function and Increases Survival in Hemorrhagic Shock. JCI Insight http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6171817/

Nicotinamide Mononucleotide Protects Against β-Amyloid Oligomer-Induced Cognitive Impairment and Neuronal Death. Brain Res https://doi.org/10.1016/j.brainres.2016.04.060

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLOS ONE https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24905194/

Protective effects of nicotinamide mononucleotide against oxidative stress-induced PC12 cell death via mitochondrial enhancement.PharmaNutrition https://www.sciencedirect.com/science/article/pii/S2213434419301872

Short-term Administration of Nicotinamide Mononucleotide Preserves Cardiac Mitochondrial Homeostasis and Prevents Heart Failure. J Mol Cell Cardiol http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6257991/

NAD+ Deficits in Age-related Diseases and Cancer. Trends in Cancer https://pubmed.ncbi.nlm.nih.gov/28780936-nad-deficits-in-age-related-diseases-and-cancer/

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence Cell metabolism https://pubmed.ncbi.nlm.nih.gov/29514064-therapeutic-potential-of-nad-boosting-molecules-the-in-vivo-evidence/

It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging and Mechanisms of Diseasehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514996/pdf/npjamd201617.pdf

Nicotinamide Mononucleotide Supplementation Reverses Vascular Dysfunction and Oxidative Stress With Aging in Mice. Aging Cell https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854911/

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice . Cell metabolism https://www.sciencedirect.com/science/article/pii/S1550413111003469

The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signalling. Cell https://www.sciencedirect.com/science/article/pii/S0092867413007551

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journalhttps://www.embopress.org/doi/full/10.15252/embj.201386907

NAD+ Therapy in Age-related Degenerative Disorders: A benefit/risk analysis. Experimental Gerontology https://pubmed.ncbi.nlm.nih.gov/31917996-nad-therapy-in-age-related-degenerative-disorders-a-benefitrisk-analysis/

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH☆. Journal of Molecular and Cellular Cardiology https://www.sciencedirect.com/science/article/pii/S0022282818303614

The first human clinical study for NMN has started in Japan. npj Aging and Mechanisms of Disease. https://www.nature.com/articles/npjamd201621.pdf

Resveratrol

Resveratrol is polyphenol in red wine. Many studies have demonstrated meaningful cardiovascular benefits, improved outcomes for those with Alzheimer’s disease, anticancer properties, antimicrobial effects, skin care benefits and sirtuin activation, specifically SIRT1 which is employed in employed recombinational repair of DNA breaks.

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM. Cells. https://www.mdpi.com/2073-4409/7/12/235

Resveratrol preserves mitochondrial function in a human post-mitotic cell model. J Nutr Biochem. https://www.ncbi.nlm.nih.gov/pubmed/30216747

Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism. J Nutr Biochem. https://www.ncbi.nlm.nih.gov/pubmed/29268122

Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients. Nutrients. https://www.ncbi.nlm.nih.gov/pubmed/25329968

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. https://www.ncbi.nlm.nih.gov/pubmed/20080969

Resveratrol inhibits ovarian tumor growth in an in vivo mouse model.Cancer https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.29793

The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials.Obesity Reviews https://pubmed.ncbi.nlm.nih.gov/27456934/

SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM.Cells https://www.mdpi.com/2073-4409/7/12/235

Resveratrol preserves mitochondrial function in a human post-mitotic cell model.J Nutr Biochem https://www.ncbi.nlm.nih.gov/pubmed/30216747

Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism.J Nutr Biochem https://www.ncbi.nlm.nih.gov/pubmed/29268122

Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients.Nutrients https://www.ncbi.nlm.nih.gov/pubmed/25329968

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.J Biol Chem https://www.ncbi.nlm.nih.gov/pubmed/20080969

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.Scientific Reports https://www.nature.com/articles/srep21772

Effects of Resveratrol in Goto-Kakizaki Rat, a Model of Type 2 Diabetes.Nutrients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836277/

Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells.Cancer Letters https://www.sciencedirect.com/science/article/abs/pii/S0304383515007223

Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.Journal of cellular physiology https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.25443

Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death.Cell Death & Disease https://www.nature.com/articles/cddis20166#Sec9

A meta-analysis of resveratrol protects against myocardial ischemia/reperfusion injury: evidence from small animal studies and insight into molecular mechanisms.Oxidative Medicine and Cellular Longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512035/pdf/OMCL2019-5793867.pdf

Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.Critical Reviews in Food Science and Nutrition
https://www.tandfonline.com/doi/abs/10.1080/10408398.2017.1349076?journalCode=bfsn20″,”Journal Link “

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis.Ageing Research Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235673/pdf/nihms-987635.pdf

Resveratrol levels and all-cause mortality in older community-dwelling adults.JAMA Internal Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346286/pdf/nihms665943.pdf

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.American Journal of Clinical Nutrition https://academic.oup.com/ajcn/article/91/6/1590/4597194

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease.Journal of Neuroinflammation https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0779-0

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.Aging https://pubmed.ncbi.nlm.nih.gov/28611316-effects-of-resveratrol-curcumin-berberine-and-other-nutraceuticals-on-aging-cancer-development-cancer-stem-cells-and-micrornas/

Effect of resveratrol on cognitive and memory performance and mood: a meta-analysis of 225 patients.Pharmacological Research https://pubmed.ncbi.nlm.nih.gov/28844841-effect-of-resveratrol-on-cognitive-and-memory-performance-and-mood-a-meta-analysis-of-225-patients/

Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells.Drug Des Devel Ther https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30863014/

Combined metformin and resveratrol confers protection against UVC-induced DNA damage in A549 lung cancer cells via modulation of cell cycle checkpoints and DNA repair.Oncol Rep https://www.ncbi.nlm.nih.gov/pubmed/27109601

Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.J Agric Food Chem https://www.ncbi.nlm.nih.gov/pubmed/19928762

Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.American journal of physiology – heart and circulatory physiology https://www.physiology.org/doi/full/10.1152/ajpheart.00455.2016

The effect of resveratrol on longevity across species: a meta-analysis.Biology Letters https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440975/

Effect of resveratrol and pterostilbene on aging and longevity.Biofactors https://pubmed.ncbi.nlm.nih.gov/29210129-effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity/

Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.Clinical Nutrition https://pubmed.ncbi.nlm.nih.gov/24731650-effect-of-resveratrol-on-blood-pressure-a-meta-analysis-of-randomized-controlled-trials/

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis.Cancer Research https://cancerres.aacrjournals.org/content/70/22/9003

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease.The American Journal of Cardiology https://www.ajconline.org/article/S0002-9149(12)01046-6/fulltext

Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.Nutrition https://www.sciencedirect.com/science/article/abs/pii/S0899900718306142

A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones.Journal of Translational Medicine https://www.sciencedirect.com/science/article/abs/pii/S0899900718306142

Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta‐analysis.Annals of the New York Academy of Sciences https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14226

Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors – results from a systematic review and meta-analysis of randomized controlled trials.International Journal of Cardiology https://pubmed.ncbi.nlm.nih.gov/25885871-lack-of-efficacy-of-resveratrol-on-c-reactive-protein-and-selected-cardiovascular-risk-factors-results-from-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials/

Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer.Nutrition and Cancer https://www.tandfonline.com/doi/full/10.1080/01635581.2012.654926?scroll=top&needAccess=true

The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Food and Function https://pubs.rsc.org/en/content/articlelanding/2018/FO/C8FO01259H#!divAbstract

Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells.Scientific Reports https://www.nature.com/articles/s41598-019-50416-5

Effect of resveratrol on lipid profile: An updated systematic review and meta-analysis on randomized clinical trials.Pharamcological Research https://www.sciencedirect.com/science/article/abs/pii/S1043661817311593?via%3Dihub

Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis.Obesity https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22348

A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma.British Journal of Haematology https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.12154

Berberine

Berberine appears to work by slowing a metabolic pathway that causes inflammation and increasing activity of the AMPK enzyme and its downstream targets, including mTOR and SIRT1 (much like the prescription drug metformin). It supports healthy blood sugar levels, promotes cardiovascular health and weight loss.

Berberine lowers blood glucose in type 2 diabetes melitus patients through increasing insulin receptor expression. Metabolism Clinical and Experimental. https://pubmed.ncbi.nlm.nih.gov/19800084-berberine-lowers-blood-glucose-in-type-2-diabetes-mellitus-patients-through-increasing-insulin-receptor-expression/

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature. https://pubmed.ncbi.nlm.nih.gov/15531889-berberine-is-a-novel-cholesterol-lowering-drug-working-through-a-unique-mechanism-distinct-from-statins/

Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled studyBerberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. The Lancet. h ttps://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30409-1/fulltext

Efficacy and safety of berberine for congestive heart failure secondarto ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology. https://pubmed.ncbi.nlm.nih.gov/12860219-efficacy-and-safety-of-berberine-for-congestive-heart-failure-secondary-to-ischemic-or-idiopathic-dilated-cardiomyopathy/

Combination of simvastatin with berberine improves the lipid-lowering efficacy. Metabolism Clinical and Experimental https://pubmed.ncbi.nlm.nih.gov/18640378-combination-of-simvastatin-with-berberine-improves-the-lipid-lowering-efficacy/

Berberine lowers blood glucose in type 2 diabetes melitus patients through increasing insulin receptor expression. Metabolism Clinical and Experimental https://pubmed.ncbi.nlm.nih.gov/19800084-berberine-lowers-blood-glucose-in-type-2-diabetes-mellitus-patients-through-increasing-insulin-receptor-expression/

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine https://pubmed.ncbi.nlm.nih.gov/15531889-berberine-is-a-novel-cholesterol-lowering-drug-working-through-a-unique-mechanism-distinct-from-statins/

Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. The Lancet Gastroenterology and Hepatology

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30409-1/fulltext

berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistance states. Diabetes https://diabetes.diabetesjournals.org/content/diabetes/55/8/2256.full.pdf

Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. Journal of Clinical Endocrinology and Metabolism https://pubmed.ncbi.nlm.nih.gov/18397984-treatment-of-type-2-diabetes-and-dyslipidemia-with-the-natural-plant-alkaloid-berberine/

Combined nutraceutical approach to postmenopausal syndrome and vascular remodeling biomarkers. The Journal of Alternative and Complementary Medicine https://pubmed.ncbi.nlm.nih.gov/23308361-combined-nutraceutical-approach-to-postmenopausal-syndrome-and-vascular-remodeling-biomarkers/

Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. Arzneimittel Forschung – Drug Research https://pubmed.ncbi.nlm.nih.gov/17341006-eulipidemic-effects-of-berberine-administered-alone-or-in-combination-with-other-natural-cholesterol-lowering-agents-a-single-blind-clinical-investigation/

Efficacy and safety of berberine for congestive heart failure secondarto ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology https://pubmed.ncbi.nlm.nih.gov/12860219-efficacy-and-safety-of-berberine-for-congestive-heart-failure-secondary-to-ischemic-or-idiopathic-dilated-cardiomyopathy/

Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women. Gynecological Endocrinology https://pubmed.ncbi.nlm.nih.gov/22313171-activity-of-isoflavones-and-berberine-on-vasomotor-symptoms-and-lipid-profile-in-menopausal-women/

Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arteriosclerosis, Thrombosis, and Vascular Biology https://pubmed.ncbi.nlm.nih.gov/16100034-extracellular-signal-regulated-kinase-dependent-stabilization-of-hepatic-low-density-lipoprotein-receptor-mrna-by-herbal-medicine-berberine/

Improvement of superoxide dismutase and catalase in streptozotocin-nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide. Pharmaceutical Biology https://pubmed.ncbi.nlm.nih.gov/24188560-improvement-of-superoxide-dismutase-and-catalase-in-streptozotocin-nicotinamide-induced-type-2-diabetes-in-mice-by-berberine-and-glibenclamide/

Effects of a new nutraceutical formulation (berberine, red yeast rice and chitosan) on non-HDL cholesterol levels in individuals with dyslipidemia: results from a randomized, double blind, placebo-controlled study. International Journal of Molecular Sciences https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535988/pdf/ijms-18-01498.pdf

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer’s disease transgenic mouse model. Neurobiology of Aging https://www.sciencedirect.com/science/article/abs/pii/S0197458012001613

Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice. Journal of Cellular and Molecular Medicine https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.12645

Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. Clinical and Experimental Pharmacology and Physiology https://pubmed.ncbi.nlm.nih.gov/22220931-berberine-ameliorates-inflammation-in-patients-with-acute-coronary-syndrome-following-percutaneous-coronary-intervention/

Berberine improves glucose metabolism through induction of glycolysis. American Journal of Physiology, Endocrinology and Metabolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464622/pdf/nihms50546.pdf

Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta https://pubmed.ncbi.nlm.nih.gov/20298851-effect-of-traditional-chinese-medicine-berberine-on-type-2-diabetes-based-on-comprehensive-metabonomics/

The preconditioning of berberine suppresses hydrogen peroxide-induced premature senescence via regulation of Sirtuin 1. Oxidative medicine and Cellular Longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511663/

Berberine alleviates amyloid beta-induced mitochondrial dysfunction and synaptic loss.Oxidative medicine and Cellular Longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525905/pdf/OMCL2019-7593608.pdf

A Phase I Trial of Berberine in Chinese with Ulcerative Colitis.Cancer Prevention Research https://cancerpreventionresearch.aacrjournals.org/content/early/2019/10/11/1940-6207.CAPR-19-0258

Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition.Cell Death and Disease https://www.nature.com/articles/cddis2017471

Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats.Clinical and Experimental Hypertension https://www.tandfonline.com/doi/abs/10.3109/10641963.2014.972560

Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice.International Immunopharmacology https://www.sciencedirect.com/science/article/pii/S1567576916302661

Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model.Am J Plant Sci https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498585/

Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy.Molecular and Cellular Endocrinology https://www.sciencedirect.com/science/article/abs/pii/S0303720717300138

Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats.The journal of nutrition, health & aging https://link.springer.com/article/10.1007/s12603-018-1015-7

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans.International Journal of Cardiology https://www.sciencedirect.com/science/article/abs/pii/S0167527312002951

Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson’s disease.International Journal of Molecular Medicine https://www.spandidos-publications.com/ijmm/33/4/870?text=fulltext

Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster.Am J Plant Sci https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498586/

Berberine suppresses neuroinflammatory responses through AMP‐activated protein kinase activation in BV‐2 microglia.European Journal of Pharmacology https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.22580

Effects of berberine on β-secretase activity in a rabbit model of Alzheimer’s disease.Arch Med Sci https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598150/

Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats.Chinese Medicine https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-5-33

Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in rats.European Journal of Pharmacology https://www.sciencedirect.com/science/article/pii/S0014299916300188

Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer’s-like disease in rats.Food and Chemical Toxicology https://www.sciencedirect.com/science/article/pii/S0278691517306932

Antitumor effect of novel berberine derivatives in breast cancer cells.BioFactors https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/biof.1131

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.Behavioural Brain Research https://doi.org/10.1016/j.bbr.2011.01.022

Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice.Rejuvenation Research https://www.liebertpub.com/doi/full/10.1089/rej.2017.1972

Berberine modulates insulin signaling transduction in insulin-resistant cells.Molecular and Cellular Endocrinology https://europepmc.org/article/med/20036710

Effect of berberine on regression of pressure-overload induced cardiac hypertrophy in rats.The American Journal of Chinese Medicine https://pubmed.ncbi.nlm.nih.gov/12568286-effect-of-berberine-on-regression-of-pressure-overload-induced-cardiac-hypertrophy-in-rats/

Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis.BMC Cancer https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5791-1

Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies.BMC Complementary and Alternative Medicine volume https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2510-z

Berberine Reverses Epithelial-to-Mesenchymal Transition and Inhibits Metastasis and Tumor-Induced Angiogenesis in Human Cervical Cancer Cells.Molecular Pharmacology http://molpharm.aspetjournals.org/content/86/6/609

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine.The Journal of Clinical Endocrinology & Metabolism https://academic.oup.com/jcem/article/93/7/2559/2598635

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.Plos One https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134172

Fisetin

Fisetin is a senotherapeutic that extends health and lifespan.EbIoMedicine https://www.sciencedirect.com/science/article/pii/S2352396418303736

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice.Aging Cell https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12185

Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies.Trends in Food Science & Technology https://www.sciencedirect.com/science/article/abs/pii/S0924224417302091

GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae Through β-Catenin Activation.Int J Mol Sci https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31906440/

Exploring the molecular targets of dietary flavonoid fisetin in cancer.Seminars in Cancer Biology https://www.sciencedirect.com/science/article/pii/S1044579X16300128

Fisetin is a senotherapeutic that extends health and lifespan.EbIoMedicine https://www.sciencedirect.com/science/article/pii/S2352396418303736

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice.Aging Cell https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12185

GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae Through β-Catenin Activation.Int J Mol Sci https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31906440/

Exploring the molecular targets of dietary flavonoid fisetin in cancer.Seminars in Cancer Biology https://www.sciencedirect.com/science/article/pii/S1044579X16300128

Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.Food and Function https://pubs.rsc.org/en/content/articlelanding/2018/FO/C7FO01898C#!divAbstract

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse.The Journals of Gerontology https://academic.oup.com/biomedgerontology/article/73/3/299/3860587

Fisetin and 5‐fluorouracil: Effective combination for PIK3CA‐mutant colorectal cancer.The International Journal of Cancer https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32367

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463.Aging https://www.aging-us.com/article/101202/text

Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice.Molecular Neurobiology https://link.springer.com/article/10.1007/s12035-016-9795-4

Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling.The Journal of Nutritional Biochemistry https://www.sciencedirect.com/science/article/abs/pii/S0955286319301408

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.Scientific reports https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32076073/

Fisetin protects against hepatosteatosis in mice by inhibiting miR‐378.Molecular Nutrition & Food Research https://doi.org/10.1002/mnfr.201300071

Fisetin Antagonizes Cell Fusion, Cytoskeletal Organization and Bone Resorption in RANKL-differentiated Murine Macrophages.J Nutr Biochem https://pubmed.ncbi.nlm.nih.gov/24524902-fisetin-antagonizes-cell-fusion-cytoskeletal-organization-and-bone-resorption-in-rankl-differentiated-murine-macrophages/?from_term=fisetin&from_filter=years.2013-2013&from_size=20&from_pos=6

Fisetin Regulates Obesity by Targeting mTORC1 Signaling.J Nutr Biochem https://doi.org/10.1016/j.jnutbio.2013.01.003

Fisetin Exerts Antihyperalgesic Effect in a Mouse Model of Neuropathic Pain: Engagement of Spinal Serotonergic System.Scientific reports https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25761874/

Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Tria.Clinical and Applied Thrombosis/Hemostasis https://journals.sagepub.com/doi/full/10.1177/1076029619871359

Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally aged rats.Archives of Physiology and Biochemistry https://www.tandfonline.com/doi/abs/10.1080/13813455.2019.1662452

Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.European Journal of Pharmacology https://www.sciencedirect.com/science/article/abs/pii/S0014299919307009

Flavonoid Fisetin Alleviates Kidney Inflammation and Apoptosis via Inhibiting Src-mediated NF-κB p65 and MAPK Signaling Pathways in Septic AKI Mice.Biomedicine & pharmacotherapy https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(19)35394-6

Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson’s Disease.J Diet Suppl https://www.tandfonline.com/doi/full/10.1080/19390211.2019.1710646

Fisetin Regulates Gut Microbiota to Decrease CCR9 +/CXCR3 +/CD4 + T-lymphocyte Count and IL-12 Secretion to Alleviate Premature Ovarian Failure in Mice.Am J Transl Res https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32051749/

Cytoprotective Effects of Fisetin Against Hypoxia-Induced Cell Death in PC12 Cells.Food Funct https://doi.org/10.1039/c4fo00948g

Fisetin Inhibits TNF-α-induced Inflammatory Action and Hydrogen Peroxide-Induced Oxidative Damage in Human Keratinocyte HaCaT Cells Through PI3K/AKT/Nrf-2-mediated Heme oxygenase-1 Expression.Int Immunopharmacol https://doi.org/10.1016/j.intimp.2015.11.014

Fisetin Imparts Neuroprotection in Experimental Diabetic Neuropathy by Modulating Nrf2 and NF-κB Pathways.Cellular and Molecular Neurobiology https://doi.org/10.1007/s10571-015-0272-9

Fisetin Inhibits UVB-induced Cutaneous Inflammation and Activation of PI3K/AKT/NFκB Signaling Pathways in SKH-1 Hairless Mic.Photochem Photobiol https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25169110/

Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats.Endocrine https://link.springer.com/article/10.1007%2Fs12020-012-9866-x

Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system.In Vitro Cellular & Developmental Biology – Animal https://link.springer.com/article/10.1007%2Fs11626-013-9681-6

Fisetin Ameliorates Oxidative Stress, Inflammation and Apoptosis in Diabetic Cardiomyopathy.Life Sci https://pubmed.ncbi.nlm.nih.gov/30742869-fisetin-ameliorates-oxidative-stress-inflammation-and-apoptosis-in-diabetic-cardiomyopathy/?from_term=fisetin&from_filter=years.2019-2019&from_pos=4

Fisetin Alleviates Atrial Inflammation, Remodeling, and Vulnerability to Atrial Fibrillation After Myocardial Infarction.Int Heart J https://www.jstage.jst.go.jp/article/ihj/60/6/60_19-131/_article

The plant flavonoid, fisetin alleviates cigarette smoke‐induced oxidative stress, and inflammation in Wistar rat lungs.The Journal of Food Biochemistry https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12962

Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol.Experimental and Therapeutic Medicine https://www.spandidos-publications.com/10.3892/etm.2019.8328

Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson’s Disease.Journal of Dietary Supplements https://www.tandfonline.com/doi/abs/10.1080/19390211.2019.1710646?journalCode=ijds20

Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation.Phytomedicine https://www.sciencedirect.com/science/article/abs/pii/S0944711318304707

Vitamin D

Vitamin D regulates the absorption of calcium and phosphorus, facilitates a normal immune system, promotes cardiovascular health, supports weight loss, and regulates insulin levels which supports diabetes prevention and management.

1,25-Dihydroxyvitamin D Protects Against Age-Related Osteoporosis by a Novel VDR-Ezh2-p16 Signal Axis. Aging cell. https://www.ncbi.nlm.nih.gov/pubmed/31880094

Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis. J Physiol. https://www.ncbi.nlm.nih.gov/pubmed/28949008

Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. Sci Rep. https://www.ncbi.nlm.nih.gov/pubmed/29769621

Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas.JAMA Oncology https://jamanetwork.com/journals/jamaoncology/fullarticle/2593044?resultClick=1

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis. A Review.JAMA Neurology https://jamanetwork.com/journals/jamaneurology/article-abstract/2679039?resultClick=1

Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years. The VDAART Randomized Clinical Trial.JAMA https://jamanetwork.com/journals/jama/fullarticle/2484339

1,25-Dihydroxyvitamin D Protects Against Age-Related Osteoporosis by a Novel VDR-Ezh2-p16 Signal Axis.Aging cell https://www.ncbi.nlm.nih.gov/pubmed/31880094

Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial.The Journal of Allergy and Clinical Immunology https://www.jacionline.org/article/S0091-6749(17)30575-4/fulltext

Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort.JAMA Neurology https://jamanetwork.com/journals/jamaneurology/fullarticle/2499458

Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality.A Systematic Review and Meta-analysis.JAMA Pediatrics https://jamanetwork.com/journals/jamapediatrics/fullarticle/2681636?resultClick=1

Vitamin D supplementation for women during pregnancy.Cochrane Database of Systematic Reviews https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008873.pub4/full?highlightAbstract=d%7Cvitamine%7Cvitamin

High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial.Annals of Internal Medicine https://annals.org/aim/fullarticle/1033290/high-doses-vitamin-d-reduce-exacerbations-chronic-obstructive-pulmonary-disease?searchresult=1

Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction.New England Journal of Medicine https://www.nejm.org/doi/full/10.1056/NEJMoa1906137

Vitamin D supplementation for prevention of mortality in adults.Cochrane Database of Systematic Reviews https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007470.pub3/full?highlightAbstract=d%7Cvitamine%7Cvitamin

Effects of Vitamin D Supplementation on Muscle Strength in Athletes: A Systematic Review.J Strength Cond Res https://www.ncbi.nlm.nih.gov/pubmed/27379960

Vitamin D Deficiency: Effects on Oxidative Stress, Epigenetics, Gene Regulation, and Aging.Biology (Basel) https://www.ncbi.nlm.nih.gov/pubmed/31083546

Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases.Sci Rep https://www.ncbi.nlm.nih.gov/pubmed/29769621

25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.Steroids https://www.ncbi.nlm.nih.gov/pubmed/31917967

Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).Nutr Neurosci https://www.ncbi.nlm.nih.gov/pubmed/31524100

Serum Vitamin D and Age-Related Muscle Loss in Afro-Caribbean Men: The Importance of Age and Diabetic Status.J Frailty Aging https://pubmed.ncbi.nlm.nih.gov/31237313/

Vitamin D in Relation to Incident Sarcopenia and Changes in Muscle Parameters Among Older Adults: The KORA-Age Study.Calcif Tissue Int https://pubmed.ncbi.nlm.nih.gov/31069442

Age-dependent expression of the vitamin D receptor and the protective effect of vitamin D receptor activation on H2O2-induced apoptosis in rat intervertebral disc cells.J Steroid Biochem Mol Biol https://www.ncbi.nlm.nih.gov/pubmed/30905826

Age-related deterioration of saccule-related neural function is associated with decreased estimated glomerular filtration rate and increased free thyroxine.Prostate https://pubmed.ncbi.nlm.nih.gov/29508414/

Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.Invest Ophthalmol Vis Sci https://pubmed.ncbi.nlm.nih.gov/28892825

Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer’s Disease.Mol Neurobiol https://pubmed.ncbi.nlm.nih.gov/29318446-vitamin-d-improves-neurogenesis-and-cognition-in-a-mouse-model-of-alzheimers-disease/?from_term=vitamin+d+and+alzheimer&from_pos=2

Vitamin D and the Risk of Dementia and Alzheimer Disease.Neurology https://pubmed.ncbi.nlm.nih.gov/25098535-vitamin-d-and-the-risk-of-dementia-and-alzheimer-disease/?from_term=vitamin+d+and+alzheimer&from_pos=4

A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas.New England Journal of Medicine https://www.nejm.org/doi/full/10.1056/NEJMoa1500409

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease.New England Journal of Medicine https://www.nejm.org/doi/full/10.1056/NEJMoa1809944

Effect of Vitamin D Supplementation on Relapse-Free Survival Among Patients With Digestive Tract Cancers.JAMA https://jamanetwork.com/journals/jama/fullarticle/2730111?resultClick=1

Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women.JAMA https://jamanetwork.com/journals/jama/fullarticle/2613159?resultClick=1

Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth.New England Journal of Medicine https://www.nejm.org/doi/full/10.1056/NEJMoa1800927

Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes. A Randomized Clinical Trial.JAMA https://jamanetwork.com/journals/jama/article-abstract/275530

Effect of vitamin D on bone strength in older African Americans: a randomized controlled trial.J Nutr Health Aging https://www.ncbi.nlm.nih.gov/pubmed/31938818

Vitamin D Status and Prevalent Early Age-Related Macular Degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study.J Nutr Health Aging https://pubmed.ncbi.nlm.nih.gov/28717807-vitamin-d-status-and-prevalent-early-age-related-macular-degeneration-in-african-americans-and-caucasians-the-atherosclerosis-risk-in-communities-aric-study/

Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults.JAMA https://jamanetwork.com/journals/jama/fullarticle/2667071?resultClick=1

Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis
A Randomized Controlled Trial.JAMA https://jamanetwork.com/journals/jama/fullarticle/1556148?resultClick=1
Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials. A Meta-analysis.JAMA Cardiology https://jamanetwork.com/journals/jamacardiology/article-abstract/2735646

Effect of Vitamin D Supplementation on Blood Pressure.A Systematic Review and Meta-analysis Incorporating Individual Patient Data.JAMA Internal Medicine https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2195120?resultClick=1

Vitamin D for the management of multiple sclerosis.Cochrane Database of Systematic Reviews https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008422.pub3/full?highlightAbstract=d%7Cvitamine%7Cvitamin

Vitamin K2

Vitamin K2 help regulate blood clotting, bone metabolism, and blood calcium levels. It protects against cancer, may suppress genetic processes that lead to tumor growth, helps normalize blood glucose, and reduces symptoms of anxiety and depression.

Dietary Intake of Vitamin K and Risk of Prostate Cancer in the Heidelberg Cohort of the European Prospective Investigation Into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. https://pubmed.ncbi.nlm.nih.gov/18400723-dietary-intake-of-vitamin-k-and-risk-of-prostate-cancer-in-the-heidelberg-cohort-of-the-european-prospective-investigation-into-cancer-and-nutrition-epic-heidelberg/

Does Vitamin K2 Play a Role in the Prevention and Treatment of Osteoporosis for Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials. Osteoporos Int. https://pubmed.ncbi.nlm.nih.gov/25516361-does-vitamin-k2-play-a-role-in-the-prevention-and-treatment-of-osteoporosis-for-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials/

Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: A Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model. Int J Biol Sci. https://pubmed.ncbi.nlm.nih.gov/27313492-vitamin-k2-ameliorates-damage-of-blood-vessels-by-glucocorticoid-a-potential-mechanism-for-its-protective-effects-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-a-rat-model/

Vitamin K and the Prevention of Fractures.JAMA Internal Medicine https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/410550

Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver.JAMA https://jamanetwork.com/journals/jama/fullarticle/199121

The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment.Cancer https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.21667

Vitamin K2 (Menatetrenone) for Bone Loss in Patients With Cirrhosis of The Liver.The American Journal of Gastroenterology https://journals.lww.com/ajg/Abstract/2002/04000/Vitamin_K2__Menatetrenone__for_Bone_Loss_in.36.aspx

Does Vitamin K2 Play a Role in the Prevention and Treatment of Osteoporosis for Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials.Osteoporos Int https://www.ncbi.nlm.nih.gov/pubmed/25516361

Vitamin K2 Supplementation in Haemodialysis Patients: A Randomized Dose-Finding Study.Nephrol Dial Transplant https://pubmed.ncbi.nlm.nih.gov/24285428-vitamin-k2-supplementation-in-haemodialysis-patients-a-randomized-dose-finding-study/?from_term=vitamin+k2&from_page=7&from_pos=3

Combined Treatment With Vitamin K2 and PTH Enhanced Bone Formation in Ovariectomized Rats and Increased Differentiation of Osteoblast in Vitro.Chem Biol Interact https://pubmed.ncbi.nlm.nih.gov/30639440-combined-treatment-with-vitamin-k2-and-pth-enhanced-bone-formation-in-ovariectomized-rats-and-increased-differentiation-of-osteoblast-in-vitro/?from_term=vitamin+k2&from_page=4&from_pos=1

Effect of Vitamin K2 on Progression of Atherosclerosis and Vascular Calcification in Nondialyzed Patients With Chronic Kidney Disease Stages 3-5.Pol Arch Med Wewn https://www.ncbi.nlm.nih.gov/pubmed/26176325

Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise.Altern Ther Health Med https://pubmed.ncbi.nlm.nih.gov/28646812-oral-consumption-of-vitamin-k2-for-8-weeks-associated-with-increased-maximal-cardiac-output-during-exercise/?from_term=vitamin+k2&from_page=2&from_pos=3

The Effects of Vitamin K1 and Vitamin K2 on the Proliferation, Cytokine Production and Regulatory T-cell Frequency in Peripheral Blood Mononuclear Cells of Paediatric Atopic Dermatitis Patients.Exp Dermatol https://pubmed.ncbi.nlm.nih.gov/29697859-the-effects-of-vitamin-k1-and-vitamin-k2-on-the-proliferation-cytokine-production-and-regulatory-t-cell-frequency-in-peripheral-blood-mononuclear-cells-of-paediatric-atopic-dermatitis-patients/?from_term=vitamin+k2&from_page=5&from_pos=5

Vitamin K1 and Vitamin K2 Immunopharmacological Effects on the Peripheral Lymphocytes of Healthy Subjects and Dialysis Patients, as Estimated by the Lymphocyte Immunosuppressant Sensitivity Test.J Clin Pharm Ther https://pubmed.ncbi.nlm.nih.gov/30014604-vitamin-k1-and-vitamin-k2-immunopharmacological-effects-on-the-peripheral-lymphocytes-of-healthy-subjects-and-dialysis-patients-as-estimated-by-the-lymphocyte-immunosuppressant-sensitivity-test/?from_term=vitamin+k2&from_page=2&from_pos=9

Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: A Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model.Int J Biol Sci https://pubmed.ncbi.nlm.nih.gov/27313492-vitamin-k2-ameliorates-damage-of-blood-vessels-by-glucocorticoid-a-potential-mechanism-for-its-protective-effects-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-a-rat-model/?from_term=vitamin+k2&from_page=6&from_pos=3

Vitamin K2 Improves Anxiety and Depression but Not Cognition in Rats With Metabolic Syndrome: A Role of Blood Glucose?Folia Med (Plovdiv) https://pubmed.ncbi.nlm.nih.gov/28068285-vitamin-k2-improves-anxiety-and-depression-but-not-cognition-in-rats-with-metabolic-syndrome-a-role-of-blood-glucose/?from_term=vitamin+k2&from_page=4&from_pos=10

Vitamin K 2 Alleviates Type 2 Diabetes in Rats by Induction of Osteocalcin Gene Expressi.Nutrition https://pubmed.ncbi.nlm.nih.gov/29429532-vitamin-k-2-alleviates-type-2-diabetes-in-rats-by-induction-of-osteocalcin-gene-expression/?from_term=vitamin+k2&from_page=8&from_pos=7

Effects of Vitamin K2 (Menatetrenone) on Atherosclerosis and Blood Coagulation in Hypercholesterolemic Rabbits.Jpn J Pharmacol https://pubmed.ncbi.nlm.nih.gov/9414028-effects-of-vitamin-k2-menatetrenone-on-atherosclerosis-and-blood-coagulation-in-hypercholesterolemic-rabbits/?from_term=vitamin+k2&from_page=8&from_pos=9

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.PLoS One https://pubmed.ncbi.nlm.nih.gov/27570977-vitamin-k2-induces-mitochondria-related-apoptosis-in-human-bladder-cancer-cells-via-ros-and-jnkp38-mapk-signal-pathways/?from_term=vitamin+k2&from_page=3&from_pos=1

Vitamin K2 Prevents Lymphoma in Drosophila.Sci Rep https://pubmed.ncbi.nlm.nih.gov/29213118-vitamin-k2-prevents-lymphoma-in-drosophila/?from_term=vitamin+k2&from_page=2&from_pos=6

Vitamin K2 Promotes Mesenchymal Stem Cell Differentiation by Inhibiting miR‑133a Expression.Mol Med Rep https://pubmed.ncbi.nlm.nih.gov/28447758-vitamin-k2-promotes-mesenchymal-stem-cell-differentiation-by-inhibiting-mir133a-expression/?from_term=vitamin+k2&from_page=2&from_pos=4

Vitamin K2-enhanced Liver Regeneration Is Associated With Oval Cell Expansion and Up-Regulation of matrilin-2 Expression in 2-AAF/PH Rat Model.Curr Mol Med https://pubmed.ncbi.nlm.nih.gov/24236453-vitamin-k2-enhanced-liver-regeneration-is-associated-with-oval-cell-expansion-and-up-regulation-of-matrilin-2-expression-in-2-aafph-rat-model/?from_term=vitamin+k2&from_page=6&from_pos=9

Vitamin K for the primary prevention of cardiovascular disease.Cochrane Database of Systematic Reviews https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011148.pub2/full